Solubility:Soluble in DMSO, DMF and ethanol
Storage/Stability:Store solutions at -20°C for up to 1 year.
Recommended Dilutions:Potent, reversible inhibitor of histone deacetylase at nM concentrations, which thereby induces hyperacetylation of histones. Blocks cell cycle at G1. Induces reversion of ras transformed cells to normal morphology. Inhibits IL-2 gene expression in Jurkat cells (IC50 = 73 nM) and induces immunosuppression in a mouse model.
References:1. J. Taunton et al. Science 1996 272 371
Form of Antibody:Trichostatin A[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide