Form of Antibody:BAY 11-7082(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile
Storage/Stability:Store solutions at -20°C for up to 1 year.
Recommended Dilutions:Inhibitor of cytokine-induced NF-κB phosphorylation. Inhibited NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8, in TNF treated HUVECs, with IC50’s of 5-10 μM. The inhibition of NF-κB phosphorylation and cell adhesion molecule expression and the stabilization of NF-κB were found to be irreversible effects.
References:J.W. Pierce et al. J. Biol. Chem. 1997 272 21096