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BAY 11-7082NF-κB InhibitorPDF

  • Catalog Number:

    E1B1523
  • Amount:

  • Form of Antibody:

    BAY 11-7082(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile
    CAS NO: 195462-67-7
  • PHYSICAL APPEARANCE: Off-white solid (m.p. 128-130°C)
    MOLECULAR FORMULA: C10H9NO2S
  • Molecular Weight:

    207.3
  • Purity:

    99%
  • Storage/Stability:

    Store solutions at -20°C for up to 1 year.
  • Recommended Dilutions:

    Inhibitor of cytokine-induced NF-κB phosphorylation. Inhibited NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8, in TNF treated HUVECs, with IC50’s of 5-10 μM. The inhibition of NF-κB phosphorylation and cell adhesion molecule expression and the stabilization of NF-κB were found to be irreversible effects.
  • References:

    J.W. Pierce et al. J. Biol. Chem. 1997 272 21096
    The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
  • Price:

    60$

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