Purity:98% (TLC: 10% MeOH/Methylene chloride; Rf = 0.51)
Storage/Stability:Store solutions at -20°C for up to 1 year.
Recommended Dilutions:Binds to and inhibits the FK506 binding protein (FKBP) proline rotamase. Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 to S phase. Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase.
References:1. J.Y.Chang et al. Trends Pharmacol.Sci. 1991 12 218
Form of Antibody:RapamycinCAS NO: 53123-88-9