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MG-132 Proteasome InhibitorPDF

  • Catalog Number:

    E1B1748
  • Amount:

  • PHYSICAL APPEARANCE: White solid (m.p. 120-121°C)
    MOLECULAR FORMULA: C26H41N3O5
  • Molecular Weight:

    475.6
  • Purity:

    98% (TLC: 10%MeOH/methylene chloride; Rf = 0.33). Peptide content: 100%
  • Solubility:

    Soluble in: DMSO (25 mg/ml); Ethanol (25 mg/ml)
  • Storage/Stability:

    Store, as supplied, at -80°C for up to 2 years. May be stored at -20°C for up to 1 week. Store solutions at -80°C for up to 2 months.
  • Recommended Dilutions:

    A potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM). Inhibits NF-κB activation by preventing NF-κB degradation (IC50 = 3 μM). Blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). Stimulates neurite outgrowth in PC12 cells (20 nM optimal). IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0.85 and 0.1 μM respectively.
  • References:

    1​ J.Adams and R.Stein Ann.Rep.Med.Chem. 1996 31 279
    2​ K.T.Bush et al. J.Biol.Chem. 1997 272 9086
    3​ S.Tsubuki et al. J.Biochem.(Tokyo) 1996 119 572
    The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
  • Price:

    65$

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